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| Antigenic Specificity | Spectrin beta-3 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL, Immunohistochemistry: 1:50-1:200 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Spectrin beta-3 Polyclonal Antibody. Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by R |
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| Immunogen | n/a |
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| Other Names | Spectrin beta chain, non-erythrocytic 2; SPTBN2; KIAA0302; SCA5 |
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| Gene, Accession # | Entrez: 6712; Uniprot: O15020 |
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| Catalog # | PA5-58724 |
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| Price | |
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| Order / More Info | Spectrin beta-3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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