| 产品详情 |
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| Antigenic Specificity | ErbB3 |
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| Clone | 3F10F6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1/200 - 1/1000, Western Blot: 1/500 - 1/2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ErbB3 Monoclonal Antibody (3F10F6). This gene encodes a member of the epidermal growth factor receptor family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants enc |
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| Immunogen | n/a |
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| Other Names | ERBB3;HER3; LCCS2 |
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| Gene, Accession # | Entrez: 2065; Uniprot: P21860 |
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| Catalog # | MA5-15437 |
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| Price | |
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| Order / More Info | ErbB3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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