| Edit |   |
|---|
| Antigenic Specificity | TDG |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 1:50-1:200, Western Blot: 1:1,000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | TDG Polyclonal Antibody. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. |
|---|
| Immunogen | n/a |
|---|
| Other Names | G/T mismatch-specific thymine DNA glycosylase; TDG |
|---|
| Gene, Accession # | Entrez: 6996; Uniprot: Q13569 |
|---|
| Catalog # | A304-365A-M |
|---|
| Price | |
|---|
| Order / More Info | TDG Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|