| 产品详情 |
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| Antigenic Specificity | SIK2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2.5 µg/mL, Immunofluorescence: 2.5 µg/mL, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIK2 Polyclonal Antibody. Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation. |
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| Immunogen | n/a |
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| Other Names | SIK2, Salt-inducible protein kinase 2, Serine, threonine-protein kinase SNF1-like kinase 2, SNF1LK2, QIK, LOH11CR1I |
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| Gene, Accession # | Entrez: 23235, 235344, 315649; Uniprot: Q8CFH6, Q9H0K1 |
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| Catalog # | PA5-34339 |
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| Price | |
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| Order / More Info | SIK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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