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| Antigenic Specificity | USP5/IsoT |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 10 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:1,000-1:5,000, Immunoprecipitation: 2-5 µg/mg lysate |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | USP5/IsoT Polyclonal Antibody. USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. |
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| Immunogen | n/a |
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| Other Names | Ubiquitin carboxyl-terminal hydrolase 5; Ubiquitin thiolesterase 5; Ubiquitin-specific processing protease 5; Deubiquitinating enzyme 5; Isopeptidase T |
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| Gene, Accession # | Entrez: 8078; Uniprot: P45974 |
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| Catalog # | A301-543A-T |
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| Price | |
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| Order / More Info | USP5/IsoT Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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