| 产品详情 |
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| Product Name | CFTR Inhibitor-172 |
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| Description | Purity ~95% (HPLC). A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~300nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5uM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50mM solution in DMSO. Formula: C18H10F3NO3S Solubility: DMSO Molecular Weight: 409.4 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CFTR Inhibitor-172 (CFTRinh-172, 3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217270 |
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| Price | |
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| Order / More Info | CFTR Inhibitor-172 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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