产品名称 Presenilin 1 Antibody from INVITROGEN ANTIBODIES
产品货号 MA1-751
产品价格 现货询价,电话:010-67529703
产品规格 200 µg
产品品牌 INVITROGEN ANTIBODIES
产品概述
产品详情
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Antigenic SpecificityPresenilin 1
CloneAPS 11
Host SpeciesMouse
Reactive Specieshuman, mouse, nonhuman primate, rat
IsotypeIgG1
Formatpurified
Size200 µg
Concentrationn/a
ApplicationsELISA: 4.5 µg/mL, Immunocytochemistry: Assay dependent, Immunofluorescence: 0.75 µg/mL, Immunohistochemistry (Paraffin): 0.75 µg/mL, Immunohistochemistry (PFA fixed): Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: 1:100-1:1000
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DescriptionPresenilin 1 Monoclonal Antibody (APS 11). Familial Alzheimer's disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predominantly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane
Immunogenn/a
Other NamesPS1, AD3, Alzheimer Disease 3, FAD, Homo Sapiens Clone CC44 Senilin 1, PSEN1, PSNL1, S182 Protein, Senilin 1
Gene, Accession #Entrez: 19164, 29192, 5663; Uniprot: P49768, P49769, P97887
Catalog #MA1-751
Price
Order / More InfoPresenilin 1 Antibody from INVITROGEN ANTIBODIES
Product Specific ReferencesPubMed: 10340748
产品资料