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Antigenic Specificity | Presenilin 1 |
Clone | APS 11 |
Host Species | Mouse |
Reactive Species | human, mouse, nonhuman primate, rat |
Isotype | IgG1 |
Format | purified |
Size | 200 µg |
Concentration | n/a |
Applications | ELISA: 4.5 µg/mL, Immunocytochemistry: Assay dependent, Immunofluorescence: 0.75 µg/mL, Immunohistochemistry (Paraffin): 0.75 µg/mL, Immunohistochemistry (PFA fixed): Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: 1:100-1:1000 |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Presenilin 1 Monoclonal Antibody (APS 11). Familial Alzheimer's disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predominantly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane |
Immunogen | n/a |
Other Names | PS1, AD3, Alzheimer Disease 3, FAD, Homo Sapiens Clone CC44 Senilin 1, PSEN1, PSNL1, S182 Protein, Senilin 1 |
Gene, Accession # | Entrez: 19164, 29192, 5663; Uniprot: P49768, P49769, P97887 |
Catalog # | MA1-751 |
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Order / More Info | Presenilin 1 Antibody from INVITROGEN ANTIBODIES |
Product Specific References | PubMed: 10340748 |
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