| 产品详情 |
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| Antigenic Specificity | Presenilin 1 |
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| Clone | APS 18 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | ELISA: 1:1000, Immunocytochemistry: 1:50 - 1:200, Immunofluorescence: 1:50 - 1:200, Immunohistochemistry: 1:20 - 1:200, Western Blot: 1:50 - 1:250 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Presenilin 1 Monoclonal Antibody (APS 18). Familial Alzheimer's disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. Recent studies have linked mutations in presenilin 1 (PS1) and presenilin 2 (PS2) to a rapid increase in plaque accumulation. PS1 and PS2 are integral membrane proteins that contain 6-8 transmembrane domains and are predominantly localized within the endoplasmic reticulum and Golgi of neurons within the brain. Within the transmembrane |
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| Immunogen | n/a |
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| Other Names | PS1, AD3, Alzheimer Disease 3, FAD, Homo Sapiens Clone CC44 Senilin 1, PSEN1, PSNL1, S182 Protein, Senilin 1 |
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| Gene, Accession # | Entrez: 19164, 29192, 5663; Uniprot: P49768, P49769, P97887 |
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| Catalog # | MA1-752 |
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| Price | |
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| Order / More Info | Presenilin 1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 10092585, 22674268, 26778963, 9852041 |
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