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| Antigenic Specificity | IRF3 |
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| Clone | 17C2 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Immunofluorescence: Assay Dependent, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRF3 Monoclonal Antibody (17C2). Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by Ikappa-B kinase-iota and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists |
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| Immunogen | n/a |
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| Other Names | IRF3, Interferon regulatory factor 3 |
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| Gene, Accession # | Entrez: 3661; Uniprot: Q14653 |
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| Catalog # | 39-2700 |
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| Price | |
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| Order / More Info | IRF3 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15681410, 24119841 |
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