| 产品详情 |
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| Antigenic Specificity | TDP-43 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 5 µg/mL, Immunofluorescence: 20 µg/mL, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TDP-43 Polyclonal Antibody. TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3' splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. |
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| Immunogen | n/a |
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| Other Names | RP4-635E18.2, ALS10, TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43 |
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| Gene, Accession # | Entrez: 230908, 23435, 298648; Uniprot: Q13148, Q921F2 |
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| Catalog # | PA5-20408 |
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| Price | |
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| Order / More Info | TDP-43 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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