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| Product Name | Recombinant Human C-C motif chemokine 28 protein (CCL28) (Active) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 22.5 & 34.7kDa. Heterodimer: 23-219aa & 23-328aa. tag-Free. Homo sapiens (Human). IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.Human and mouse IL-12 share 70% and 60% amino acid sequence identity in their p40 and p35 subunits, respectively. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-?) and tumor necrosis factor-alpha (TNF-a) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-?. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity.IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; NK cell; IL12A; NKSF1 stimulatory factor chain 1; |
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| Gene, Accession, CAS # | IL12, UniProt: P29459 & P29460 |
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| Catalog # | RPC26915 |
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| Order / More Info | Recombinant Human C-C motif chemokine 28 protein (CCL28) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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