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| Product Name | Protein Phosphatase 2C alpha, Recombinant, Human |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Protein phosphatase 2C alpha, also called PP2Calpha, Protein Phosphatase, Magnesium-dependent type 1A, and PPM1A, dephosphorylates proteins with some preference for phospho-threonine over phospho-serine residues 1. It is insensitive to the PP1 and PP2a inhibitors such as okadaic acid 2, but has an absolute requirement for either magnesium or manganese ions 3 and can be activated by unsaturated fatty acids such as arachidonic and oleic acids 4. Overexpression of PP2Calpha causes G2/M cell cycle arrest and apoptosis that has been associated with the activation of p53 5. Dephosphorylation of proteins in the nucleus by PP2Calpha is suspected to play a role in terminating or reducing the sensitivity of the responses to SMADS 6 and stress-activated proteins such as p38 and JNK 7. Source: E. coli-expressed recombinant protein. Molecular Mass: Amino acid residues 1-324 of PP2Calpha (Accession # NP_808820) with a C-terminal |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Protein Phosphatase 2C alpha, Recombinant, Human (PP2Ca, PPM1A, Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A) |
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| Gene, Accession, CAS # | Accession: NP_808820 |
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| Catalog # | P9107-37B |
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| Order / More Info | Protein Phosphatase 2C alpha, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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