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| Product Name | PRMT5/MEP50, Recombinant, Human, FLAG-Avi-Tag/His-Tag (Biotin) |
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| Description | Purity ~90% (SDS-PAGE). Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer Source: Recombinant protein corresponding to the complex of human PRMT5 (GenBank Accession No. NM_006109), aa2-637(end), with N-terminal FLAG-Avi tag, and human MEP50 (GenBank Accession No. NM_024102) with N-terminal His-Tag, aa2-342(end), coexpressed in HEK293 cells. Molecular Weight: ~73kD (PRMT5), ~38kD (MEP50) AA |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HRMT1L5, IBP72, JBP1, SKB1, PRMT Protein |
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| Gene, Accession, CAS # | Accession: NM_006109 (PRMT5), NM_024102 (MEP50) |
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| Catalog # | 377013 |
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| Order / More Info | PRMT5/MEP50, Recombinant, Human, FLAG-Avi-Tag/His-Tag (Biotin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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