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| Product Name | Plasminogen Activator Inhibitor Type 1, active, Rat Assay Kit, BioAssay™ (PAI-1) |
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| Description | Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma. It is a member of the serine proteinase inhibitor (serpin) superfamily. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). PAI-1 is the primary inhibitor of tissue-type plasminogen activator (tPA) and the urokinase-type plasminogen activator (uPA). This inhibition exhibits antiproteolytic properties that can lead to myocardial infarction, thromboembolic disease with elevated levels of PAI-1. PAI-1 is thought to play a role in the function of tissue remodeling, angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4256-37 |
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| Order / More Info | Plasminogen Activator Inhibitor Type 1, active, Rat Assay Kit, BioAssay™ (PAI-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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