| 产品详情 |
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| Product Name | Chenodeoxycholic Acid |
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| Description | Purity >95%. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis. Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. EC50 concentrations for activation of FXR range from 13-34 µM. In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2. CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3a,7a-dihydroxy-5Beta-cholan-24-oic acid, Anthropodeoxycholic acid, CDCA, Fluibil, Hekbilin, Kebilis, Ulmenide |
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| Gene, Accession, CAS # | CAS: 474-25-9 |
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| Catalog # | LS-H7105 |
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| Price | |
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| Order / More Info | Chenodeoxycholic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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