| 产品详情 |
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| Antigenic Specificity | LATS1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 20 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LATS1 Polyclonal Antibody. LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supp |
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| Immunogen | n/a |
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| Other Names | LATS (large tumor suppressor, Drosophila) homolog 1; WARTS protein kinase; h-warts; large tumor suppressor homolog 1; serine/threonine-protein kinase LATS1 |
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| Gene, Accession # | Entrez: 16798, 9113; Uniprot: O95835, Q8BYR2 |
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| Catalog # | A300-477A-T |
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| Price | |
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| Order / More Info | LATS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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