| 产品详情 |
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| Antigenic Specificity | BCAS2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 5 µg/mL, Western Blot: 0.5-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BCAS2 Polyclonal Antibody. BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53-null or -mutant cells; this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as |
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| Immunogen | n/a |
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| Other Names | DAM1, SPF27, Snt309; DNA amplified in mammary carcinoma 1 protein; breast carcinoma-amplified sequence 2; pre-mRNA-splicing factor SPF27; spliceosome associated protein, amplified in breast cancer; spliceosome-associated protein SPF 27 |
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| Gene, Accession # | Entrez: 10286, 295334, 68183; Uniprot: O75934, Q9D287 |
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| Catalog # | PA5-20905 |
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| Price | |
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| Order / More Info | BCAS2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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