| 产品详情 |
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| Product Name | GS967 |
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| Description | Purity >98%. Inhibition of cardiac late sodium current (late INa ) is a strategy to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure. GS967 is a selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and hearts. It can inhibit A. sulcata toxin II-induced late INa in ventricular myocytes and isolated hearts with IC50 values of 0.13 and 0.21 µM, respectively. GS967 causes minimal inhibition of the delayed-rectifier potassium current nor does it affect L- or T-type calcium channel currents, sodium-calcium exchanger currents, or a panel of 162 receptors, ion channels, transporters, and enzymes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine |
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| Gene, Accession, CAS # | CAS: 1262618-39-2 |
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| Catalog # | LS-H7986 |
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| Order / More Info | GS967 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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