| 产品详情 |
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| Product Name | GS-9973 |
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| Description | Purity >95%. Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRGamma chains and mediates downstream signaling related to platelet function and inflammation. GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates 10-35-fold selectivity for Syk over a panel of 359 nonmutant kinases. In conjunction with the PI3KDelta inhibitor CAL-101 , it has been used to reduce chronic lymphocytic leukemia cell survival and to disrupt chemokine signaling at nanomolar concentrations. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-imidazo[1,2-a]pyrazin-8-amine |
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| Gene, Accession, CAS # | CAS: 1229208-44-9 |
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| Catalog # | LS-H7987 |
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| Price | |
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| Order / More Info | GS-9973 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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