| 产品详情 |
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| Product Name | CJ-023423 |
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| Description | Purity >98%. Prostaglandin E2 (PGE2 ) activates four E prostanoid (EP) receptors, EP1-4 . EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively). It inhibits PGE2 -evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection of PGE2 . CJ-023423 reduces acute and chronic inflammatory pain in different mouse models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[[2,4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenylethylamino]carbonyl]-4-methyl-benzenesulfonamide, RQ-00000007 |
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| Gene, Accession, CAS # | CAS: 415903-37-6 |
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| Catalog # | LS-H7180 |
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| Price | |
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| Order / More Info | CJ-023423 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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