| 产品详情 |
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| Antigenic Specificity | ICAD |
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| Clone | OTI1B10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Western Blot: 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ICAD Monoclonal Antibody (OTI1B10). ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then |
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| Immunogen | n/a |
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| Other Names | H13, DFF-45, DFF1, ICAD; DFF45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; inhibitor of CAD |
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| Gene, Accession # | Entrez: 1676; Uniprot: O00273 |
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| Catalog # | MA5-24888 |
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| Price | |
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| Order / More Info | ICAD Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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