| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | ICAD |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 ug |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot: 1:1000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | ICAD Polyclonal Antibody. ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released f |
|---|
| Immunogen | n/a |
|---|
| Other Names | RP23-121D17.3, A330085O09Rik, DFF35, Dff45, ICAD, ICAD-L, ICAD-S; DFF-45; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; inhibitor of CAD |
|---|
| Gene, Accession # | Entrez: 13347; Uniprot: O54786 |
|---|
| Catalog # | PA5-19890 |
|---|
| Price | |
|---|
| Order / More Info | ICAD Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|