| 产品详情 |
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| Antigenic Specificity | UVRAG |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | canine, chicken, human, mouse, nonhuman primate, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Western Blot: 0.5-1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | UVRAG Polyclonal Antibody. UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13.5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. T |
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| Immunogen | n/a |
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| Other Names | DHTX, VPS38, p63, UV radiation resistance-associated gene protein, beclin 1 binding protein, disrupted in heterotaxy |
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| Gene, Accession # | Entrez: 308846, 419091, 607998, 7405, 78610; Uniprot: Q8K245, Q9P2Y5 |
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| Catalog # | PA5-23215 |
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| Price | |
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| Order / More Info | UVRAG Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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