| 产品详情 |
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| Antigenic Specificity | Senataxin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 2-5 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Senataxin Polyclonal Antibody. Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700 |
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| Immunogen | n/a |
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| Other Names | ALS4, amyotrophic lateral sclerosis 4, amyotrophic lateral sclerosis 4 protein, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 homolog, Senataxin, spinocerebellar ataxia, recessive, non-Friedreich type 1 |
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| Gene, Accession # | Entrez: 23064; Uniprot: Q7Z333 |
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| Catalog # | A301-104A |
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| Price | |
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| Order / More Info | Senataxin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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