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| Product Name | BAY 43-9006 |
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| Description | Purity >98%. The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. BAY 43-9006 is an inhibitor of Raf-1 and B-Raf (IC50 = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRBeta, FLT3, and c-Kit (IC50 = 90, 15, 20, 57, and 58 nM, respectively). It poorly inhibits ERK1, MEK1, and several other kinases (IC50 = >10 µM). Through these effects BAY 43-9006 inhibits tumor angiogenesis and induces tumor cell apoptosis, particularly in renal cell carcinoma and hepatocellular carcinoma. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide, Sorafenib |
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| Gene, Accession, CAS # | CAS: 284461-73-0 |
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| Catalog # | LS-H6750 |
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| Order / More Info | BAY 43-9006 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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