| 产品详情 |
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| Product Name | BAY 85-3934 |
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| Description | Purity >95%. Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-dependent degradation of the Alpha subunit of HIF suppresses erythropoietin expression, stimulation of erythropoiesis by agents that prevent degradation of HIF has been one strategy for managing anemia. BAY 85-3934 stabilizes HIF from degradation in the proteasome by inhibiting HIF-1Alpha prolyl hydroxylase (IC50 = 0.49 µM). Inhibition of HIF prolyl hydroxylase by BAY 85-3934 has been shown to increase endogenous production of erythropoietin. This compound has been investigated in clinical trial for treatment of patients with anemia associated with chronic kidney disease and/or end-stage renal disease. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one, Molidustat |
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| Gene, Accession, CAS # | CAS: 1154028-82-6 |
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| Catalog # | LS-H6751 |
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| Order / More Info | BAY 85-3934 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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