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| Antigenic Specificity | GRB7 |
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| Clone | OTI15E7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GRB7 Monoclonal Antibody (OTI15E7). Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus. GRB7 maps to the region on mouse chromosome 11 containing the Neu gene. This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer. Moreover, GRB7 is amplified and over-e |
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| Immunogen | n/a |
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| Other Names | B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7; GRB7_HUMAN; Growth factor receptor bound protein 7; Growth factor receptor-bound protein 7; |
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| Gene, Accession # | Entrez: 2886; Uniprot: Q14451 |
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| Catalog # | MA5-27118 |
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| Price | |
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| Order / More Info | GRB7 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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