| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Phospho-TPL2 (Thr290) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Immunofluorescence: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Phospho-TPL2 (Thr290) Polyclonal Antibody. The role of mitogen-activated protein kinases (MAPKs) in cell signaling pathways is well established. The rat gene Tpl-2, for tumor progression locus 2, and the human and mouse homologues c-Cot, for cancer osaka thyroid oncogene, encode a proto-oncogene serine/threonine protein kinase that was shown to play a role in the functional activation of the MAP kinase pathway. Overexpression of Cot induces MAP kinase activation in COS-1 and NIH/3T3 cells. Cot-mediated activation of MAP kinase is inhibited by both Ras N17, a dominant negative mutant of c-H-Ras, and Raf-1s621A, a dominant negative mutant of Raf-1, suggesting that Cot functions upstream of Ras and Raf-1.Other studies have shown that a kinase- |
|---|
| Immunogen | n/a |
|---|
| Other Names | CCOT, COT, COT proto oncogene serine/threonine protein kinase, EST, ESTF, Ewing sarcoma transformant, FLJ10486, M3K8, MAP3K 8, MAP3K8, TPL 2, TPL-2, TPL2, Tumor progression locus 2 |
|---|
| Gene, Accession # | Entrez: 116596, 1326, 26410; Uniprot: P41279, Q07174, Q63562 |
|---|
| Catalog # | PA5-36635 |
|---|
| Price | |
|---|
| Order / More Info | Phospho-TPL2 (Thr290) Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|