| 产品详情 |
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| Antigenic Specificity | MCL1 |
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| Clone | RC13 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 500 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): Assay-Dependent, Immunoprecipitation: 2 µg / mg lysate, Western Blot: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MCL1 Monoclonal Antibody (RC13). Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. |
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| Immunogen | n/a |
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| Other Names | BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, induced myeloid leukemia cell differentiation protein Mcl-1, myeloid cell leukemia ES |
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| Gene, Accession # | Entrez: 4170; Uniprot: Q07820 |
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| Catalog # | AHO0102 |
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| Price | |
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| Order / More Info | MCL1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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