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| Product Name | Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18) (Active) |
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| Description | Purity > 98% as determined by SDS-PAGE and HPLC. MW: 14.3kDa. Partial: 74-199aa. tag-Free. Homo sapiens (Human). Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). {ECO:0000250|UniProtKB:Q7TS55, ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044, ECO:0000269|PubMed:23892569}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, hGITRL |
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| Gene, Accession, CAS # | TNFSF18,AITRL,GITRL,TL6,UNQ149/PRO175, UniProt: Q9UNG2 |
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| Catalog # | RPC26716 |
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| Order / More Info | Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (TNFSF18) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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