| 产品详情 |
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| Antigenic Specificity | PTEN |
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| Clone | 17.A |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgM, kappa |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:1-1:100, Immunofluorescence: 1:1-1:100, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:10-1:100 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PTEN Monoclonal Antibody (17.A). PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the |
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| Immunogen | n/a |
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| Other Names | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1, TEP1, Phosphatase and tensin homolog |
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| Gene, Accession # | Entrez: 19211, 5728; Uniprot: O08586, P60484 |
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| Catalog # | MA5-12278 |
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| Price | |
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| Order / More Info | PTEN Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15195502, 15307142, 16191507, 16534839, 16793127, 17083125, 17317031, 17575221, 17647268, 18509818, 19508975, 19818761, 20472435, 20566844, 21240992, 21792012, 22179774, 22229245, 25461816, 26754093, 27033068, 27260518, 27282637 |
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