| 产品详情 |
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| Antigenic Specificity | CHK2 |
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| Clone | 20A8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Immunoprecipitation: 2 µg, Western Blot: 0.1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHK2 Monoclonal Antibody (20A8). Both Chk1 and Chk2 are critically important checkpoint kinases. Chk1 is essential for normal development and cell growth and Chk1 deficiency in mouse or in embryonic stem (ES) cells is lethal. Loss of Chk2 is tolerated and has been found to be associated with a subset of Li-Fraumeni cases. Li-Fraumeni syndrome increases greatly the susceptibility to cancer, with particularly high occurrences of breast cancer, brain tumors, acute leukemia, soft tissue sarcomas, bone sarcomas, and adrenal cortical carcinoma. Chk2 regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. The cell either stops the cell cycle and therefore its proliferation until the damag |
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| Immunogen | n/a |
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| Other Names | CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; CHK2 checkpoint homolog; cds1 homolog; checkpoint-like protein CHK2; protein kinase CHK2; serine/threonine-protein kinase Chk2 |
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| Gene, Accession # | Entrez: 11200; Uniprot: O96017 |
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| Catalog # | MA5-17218 |
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| Price | |
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| Order / More Info | CHK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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