| 产品详情 |
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| Antigenic Specificity | CHK2 |
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| Clone | 2CHK01 (DCS-293) |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 500 µL |
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| Concentration | n/a |
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| Applications | Immunofluorescence: Assay Dependent, Immunoprecipitation: 2 µg/ mg protein Lystate, Western Blot: 1-3 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHK2 Monoclonal Antibody (2CHK01 (DCS-293)). Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both functionas essential components in the G2 DNA damage checkpoint by phophorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cel |
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| Immunogen | n/a |
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| Other Names | checkpoint-like protein CHK2, protein kinase CHK2, serine/threonine-protein kinase Chk2 |
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| Gene, Accession # | Entrez: 11200; Uniprot: O96017 |
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| Catalog # | MA5-11940 |
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| Price | |
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| Order / More Info | CHK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 12393693, 12493754, 19223857, 19671522 |
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