| 产品详情 |
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| Antigenic Specificity | CHK2 |
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| Clone | 73C175.1.1 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHK2 Monoclonal Antibody (73C175.1.1). Chk2 (checkpoint kinase 2) is the mammalian homolog of the Saccharomyces cerevisiae Rad53 and is required for the DNA damage and replication checkpoints (1). In response to low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia mutated (ATM)-dependent manner, Chk2 can phosphorylate the mitosis-inducing phosphatase Cdc25C on an inhibitory site, blocking entry into mitosis, and p53 on a regulatory site, causing G1 arrest (2,3). In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or at low level in static tissues such as muscle or brain (4). Mutations in Chk2 inactivat |
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| Immunogen | n/a |
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| Other Names | RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53 |
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| Gene, Accession # | Entrez: 11200, 50883; Uniprot: O96017, Q9Z265 |
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| Catalog # | MA1-41250 |
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| Price | |
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| Order / More Info | CHK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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