| 产品详情 |
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| Antigenic Specificity | Chk2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 10 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:250-1:1,000, Immunoprecipitation: 1-4 µg/mg lysate |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Chk2 Polyclonal Antibody. Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familia |
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| Immunogen | n/a |
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| Other Names | RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53 |
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| Gene, Accession # | Entrez: 11200; Uniprot: O96017 |
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| Catalog # | A300-619A-T |
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| Price | |
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| Order / More Info | Chk2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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