| 产品详情 |
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| Antigenic Specificity | CHK2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1 µg/mL, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CHK2 Polyclonal Antibody. The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2 , p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53. Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer. |
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| Immunogen | n/a |
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| Other Names | RP11-436C9.1, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1; CHK2 checkpoint homolog; cds1 homolog; checkpoint-like protein CHK2; protein kinase CHK2; serine/threonine-protein kinase Chk2 |
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| Gene, Accession # | Entrez: 11200, 114212, 50883; Uniprot: O96017, Q9Z265 |
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| Catalog # | PA5-19971 |
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| Price | |
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| Order / More Info | CHK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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