| Edit |   |
|---|
| Antigenic Specificity | FKBP12 |
|---|
| Clone | OTI3B3 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2b |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry: 1:100, Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:200-1:1000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | FKBP12 Monoclonal Antibody (OTI3B3). Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins. FKBP12:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent serine/threonine phosphatase which |
|---|
| Immunogen | n/a |
|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; EC 5.2.1.8; FK506-binding protein 1A; FKBP-1A; Rotamase; Immunophilin FKBP12; 12 kDa FKBP; FKBP-12; FKBP1A; FKBP1; FKBP12 |
|---|
| Gene, Accession # | Entrez: 2280; Uniprot: P62942 |
|---|
| Catalog # | MA5-24953 |
|---|
| Price | |
|---|
| Order / More Info | FKBP12 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|