| 产品详情 |
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| Product Name | 7BIO |
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| Description | Purity >99%. 7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC50 = 0.34 µM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50 s = 1.9 and 1.3 µM, respectively). It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 µM, respectively. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, 7-Bromoindirubin-3'-oxime |
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| Gene, Accession, CAS # | CAS: 916440-85-2 |
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| Catalog # | LS-H6275 |
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| Price | |
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| Order / More Info | 7BIO from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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