| 产品详情 |
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| Antigenic Specificity | Bcl-2 |
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| Clone | 10C4 |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 1-10 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Bcl-2 Monoclonal Antibody (10C4). BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic ge |
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| Immunogen | n/a |
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| Other Names | AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik |
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| Gene, Accession # | Entrez: 12043, 24224; Uniprot: P10417, P49950 |
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| Catalog # | MA1-12246 |
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| Price | |
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| Order / More Info | Bcl-2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11980919, 12515824, 12517945, 15184368, 16545683, 17010314, 17076656, 17599038, 18261723, 18768150, 19490089, 20956382, 22096592, 22282242 |
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