| 产品详情 |
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| Antigenic Specificity | BABAM1 |
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| Clone | GT1251 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Western Blot: 1:500-1:3000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BABAM1 Monoclonal Antibody (GT1251). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and hel |
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| Immunogen | n/a |
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| Other Names | BRISC and BRCA1 A complex member 1, BABAM1, HSPC142, NBA1, MERIT40 |
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| Gene, Accession # | Entrez: 29086; Uniprot: Q9NWV8 |
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| Catalog # | MA5-27830 |
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| Price | |
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| Order / More Info | BABAM1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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