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| Antigenic Specificity | BABAM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL, Western Blot: 1:100 - 1:250 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BABAM1 Polyclonal Antibody. HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BR |
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| Immunogen | n/a |
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| Other Names | C19orf62; MERIT40; NBA1; BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of RAP80 interactions and targeting subunit of 40 kDa; mediator of Rap80 interactions and targeting 40 kDa; new component of the BRCA1 A complex; new component of the BRCA1-A complex |
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| Gene, Accession # | Entrez: 29086; Uniprot: Q9NWV8 |
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| Catalog # | PA5-65868 |
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| Price | |
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| Order / More Info | BABAM1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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