| 产品详情 |
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| Product Name | HTS 01037 |
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| Description | Purity >98%. Adipocyte fatty acid binding protein (A-FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism. Molecular disruption of A-FABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. HTS 01037 is a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 µM) that presumably competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2. At a concentration of 10 µM, HTS 01037 antagonizes the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes. 4 HTS 01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-stimulated inflammation in bone marrow-derived macrophages, both effects of which are similar to the phenotype of A-FABP/aP2 knockout mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-[2,2'-bithiophene]-5-carboxylic acid, 5-methyl ester |
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| Gene, Accession, CAS # | CAS: 682741-29-3 |
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| Catalog # | LS-H8127 |
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| Order / More Info | HTS 01037 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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