| 产品详情 |
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| Antigenic Specificity | RIM2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RIM2 Polyclonal Antibody. Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. |
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| Immunogen | n/a |
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| Other Names | RIM2, Rab3-interacting molecule 2, regulating synaptic membrane exocytosis 2, RIMS2 |
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| Gene, Accession # | Entrez: 9699; Uniprot: Q9UQ26 |
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| Catalog # | PA5-34367 |
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| Price | |
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| Order / More Info | RIM2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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