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| Product Name | Ku-60019 |
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| Description | Purity >98%. Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro . It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | rel -2R,6S-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide |
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| Gene, Accession, CAS # | CAS: 925701-46-8 |
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| Catalog # | LS-H8376 |
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| Price | |
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| Order / More Info | Ku-60019 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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