| 产品详情 |
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| Product Name | Ku-55933 |
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| Description | Purity >98%. Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM; Ki = 2.2 nM). Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents. Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death. It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one, ATM Kinase Inhibitor |
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| Gene, Accession, CAS # | CAS: 587871-26-9 |
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| Catalog # | LS-H8373 |
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| Order / More Info | Ku-55933 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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