| 产品详情 |
| Edit |   |
|---|
| Product Name | Oltipraz |
|---|
| Description | Purity >98%. Oltipraz, originally identified as an antischistosomiasis agent, is a potent anticarcinogen in a variety of animal models of cancer at concentrations of ~200 mg/kg. It is an effective inducer of phase I and II detoxifying enzymes, including glutathione S-tranferases, UDP-glucuronosyltransferases, NAD(P)H:quinone oxidoreductase, microsomal epoxide hydrolase, and aflatoxin aldehyde reductase. Induction of these metabolic enzymes by oltipraz has been linked to the transcription factor nuclear factor E2 -related factor 2 and its activation of the antioxidant response element. In mice, oltipraz at 150 mg/kg can also induce expression of CYP2B, a gene regulated by the constitutive androstane receptor, a transcription factor important in the detoxification of endobiotic and xenobiotic substances. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione, NSC 347901, RP 35972 |
|---|
| Gene, Accession, CAS # | CAS: 64224-21-1 |
|---|
| Catalog # | LS-H9178 |
|---|
| Price | |
|---|
| Order / More Info | Oltipraz from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|