| 产品详情 |
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| Antigenic Specificity | Phospho-LAT (Tyr191) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:500-1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-LAT (Tyr191) Polyclonal Antibody. LAT, a transmembrane adaptor protein expressed in T, NK and mast cells, is an important mediator for T cell receptor (TCR) signaling. Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets. The phosphorylation of LAT at Tyr171 and 191 enables the binding of Grb2, Gads/SLP-76, PLCgamma1 and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways. |
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| Immunogen | n/a |
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| Other Names | Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT |
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| Gene, Accession # | Entrez: 16797, 27040, 81511; Uniprot: O43561, O54957, O70601 |
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| Catalog # | PA5-38291 |
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| Price | |
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| Order / More Info | Phospho-LAT (Tyr191) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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