| 产品详情 |
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| Product Name | GSK199 (hydrochloride) |
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| Description | Purity >98%. Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3. It is less potent than the related PAD4 inhibitor GSK484 , which demonstrates an IC50 value of 50 nM. GSK199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone, monohydrochloride |
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| Gene, Accession, CAS # | CAS: 1549811-53-1 |
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| Catalog # | LS-H7994 |
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| Price | |
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| Order / More Info | GSK199 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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