| 产品详情 |
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| Antigenic Specificity | SWAP70 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:20,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SWAP70 Polyclonal Antibody. SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues |
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| Immunogen | n/a |
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| Other Names | SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit |
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| Gene, Accession # | Entrez: 20947, 23075; Uniprot: Q6A028, Q9UH65 |
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| Catalog # | PA5-78432 |
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| Price | |
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| Order / More Info | SWAP70 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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