| 产品详情 |
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| Product Name | JMJD Histone Demethylase Inhibitor IV, Methylstat |
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| Description | Purity ~96% (HPLC). A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Formula: C28H31N3O6 Solubility: DMSO Molecular Weight: 505.6 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JMJD Histone Demethylase Inhibitor IV, Methylstat ((E)-Methyl-4-(hydroxy(4-((4-(((naphthalen-1-ylcarbamoyl)oxy)methyl)benzyl)amino)butyl)amino)-4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217483 |
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| Order / More Info | JMJD Histone Demethylase Inhibitor IV, Methylstat from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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